All four treatments are prescription weight loss medicines that work by helping to reduce appetite and increase feelings of fullness. The main differences are how they are taken, whether there are any food or timing restrictions, and the weight loss results seen in clinical studies.

* Based on clinical trial data when combined with diet and lifestyle changes. Individual results can vary.

Which treatment is right for me?

Foundayo® may be suitable for people who want a daily tablet with no food, drink or timing restrictions, and who would prefer not to use injections.

Wegovy® Pill is also a once-daily tablet, but it must be taken immediately after waking with a small amount of water, followed by a 30 minute wait before eating, drinking or taking other medicines.

Wegovy® Injection contains the same active ingredient as Wegovy® Pill but is administered once weekly, making it a convenient option for many patients.

Mounjaro® works slightly differently and has demonstrated the greatest average weight loss in clinical studies, making it a popular choice for patients seeking the strongest weight loss results currently available.

Our clinicians will assess your medical history, treatment preferences, and weight loss goals to help determine the most appropriate option for you.

Foundayo® is the brand name for orforglipron, a once-daily prescription tablet developed by Eli Lilly for weight management in adults. It is a GLP-1 receptor agonist, taken alongside a reduced-calorie diet and increased physical activity.

Unlike other oral treatments in this class, Foundayo® can be taken at any time of day, with or without food, and with no restriction on when you eat, drink or take your other medicines.

How Foundayo® Works

Foundayo® acts on receptors for GLP-1, a hormone your body produces naturally after eating. This can help reduce appetite, increase feelings of fullness, and support a lower calorie intake. It works alongside changes to your diet and activity rather than replacing them.

How Effective Is Foundayo®?

In the ATTAIN-1 trial, adults with obesity taking the highest strength of orforglipron for 72 weeks achieved average weight loss of approximately 12.4%, compared with around 1% on placebo. Around 60% of participants lost at least 10% of their body weight, around 40% lost at least 15%, and around 20% lost at least 20%.

Results vary from person to person and depend on the dose you reach, how well you tolerate treatment, and the changes you make to your diet and activity.

Who Can Use Foundayo®?

Foundayo® is licensed for adults who:

• have obesity (BMI of 30 kg/m² or above), or
• are overweight (BMI of 27 kg/m² or above) and have at least one weight-related health condition such as high blood pressure, high cholesterol, obstructive sleep apnoea, cardiovascular disease, or pre-diabetes

Our clinicians will assess:

• your BMI
• weight-related health conditions
• medical history
• current medications
• previous weight loss treatments

We may also ask for photographs, recent measurements, identity confirmation or details from your GP record before we make a decision.

Foundayo® and Type 2 Diabetes

Foundayo® also holds a separate licence for type 2 diabetes. The treatment described here is supplied through our weight management service. If you have diabetes, do not start, stop or change your diabetes treatment without speaking to the clinician responsible for your diabetes care.

Foundayo® should be taken exactly as prescribed by your clinician and in line with your dispensing label.

How to Take Foundayo®

Foundayo® is designed to fit around your day rather than the other way round:

• Take one tablet once daily.
• Take it at any time of day, with or without food.
• Swallow the tablet whole. Do not split, crush or chew it.
• Do not take more than one dose in a day.
• Taking it at roughly the same time each day makes it easier to remember.

Your Dose Progression

You will start on the lowest strength and move up gradually. Increasing slowly gives your body time to adjust and helps reduce digestive side effects.

The maximum dose is 17.2mg once daily. Your clinician decides whether and when to increase your dose. You will not necessarily need the highest strength, and an increase may be delayed if you are experiencing side effects.

If You Miss a Dose

Take the missed dose when you remember, as long as you have not already taken a dose that day. Do not take two tablets in one day and do not double your next dose. Continue as normal the following day.

If You Are Having Surgery or a Procedure

Tell the healthcare professional responsible for your procedure that you take Foundayo®. Medicines in this class can slow stomach emptying, which may affect anaesthesia or deep sedation.

Active ingredient: orforglipron.

Each Foundayo® tablet contains 0.8mg, 2.5mg, 5.5mg, 9mg, 14.5mg or 17.2mg of orforglipron, depending on the strength you are prescribed.

For the full list of inactive ingredients, allergens and tablet appearance, read the patient information leaflet supplied with your medicine. If you have a known allergy or intolerance, tell us during your consultation so our clinicians can check the pack before we dispense.

Like all medicines, Foundayo® can cause side effects, although not everyone gets them. Digestive effects are most common when you start treatment or after a dose increase, and they often settle as your body adjusts.

Common Side Effects

• nausea
• diarrhoea
• constipation
• vomiting
• indigestion
• stomach pain or discomfort

Drink plenty of fluid, particularly if you have vomiting or diarrhoea, as dehydration can increase the risk of complications. Contact our clinical team if symptoms are persistent, severe, or make it difficult to keep fluids down.

Getting the Right Help

If you are unsure how serious a symptom is, use the guide below:

• Mild symptoms that are settling – contact our clinical team or speak to your pharmacist.
• Symptoms that are severe, persistent or worrying you – contact your GP or call NHS 111.
• Any of the red-flag symptoms below – stop taking Foundayo® and call 999 or go to your nearest A&E.

Stop taking Foundayo® and call 999 or go to A&E if you develop:

• severe, persistent stomach pain that may spread to your back, with or without vomiting – this may be pancreatitis
• swelling of the face, lips, tongue or throat, difficulty breathing or swallowing, faintness, or a rapidly worsening rash – this may be a severe allergic reaction
• sudden loss of vision or a sudden significant change in vision
• severe constipation with stomach swelling, pain or vomiting, which may indicate a bowel obstruction

Contact your GP or call NHS 111 promptly if you develop symptoms of gallbladder problems, signs of dehydration, worsening kidney problems, or troublesome dizziness or low blood pressure. Do not wait for your next review.

Read the patient information leaflet supplied with your medicine for the full list of side effects. You can report a suspected side effect through the MHRA Yellow Card scheme.

Tell us about every prescription medicine, pharmacy medicine, vitamin, supplement and herbal product you take. Some medicines change how much Foundayo® your body absorbs, and Foundayo® can do the same to others.

Medicines that can increase your exposure to Foundayo®

• clarithromycin
• itraconazole or ketoconazole
• ritonavir or telaprevir

Medicines that can reduce your exposure to Foundayo®

• carbamazepine
• bosentan
• efavirenz
• rifampicin
• phenytoin
• St Johns Wort

Medicines Foundayo® can affect

Foundayo® may change your exposure to simvastatin, rosuvastatin and topotecan. Our clinicians may review your monitoring, the timing of your doses, or whether a different treatment suits you better.

If you use insulin or a sulfonylurea for diabetes, your risk of low blood sugar may be higher. Any change to those medicines must be made by the clinician responsible for your diabetes care.

Oral Contraception

Foundayo® may reduce the effectiveness of contraceptive pills. If you take an oral contraceptive, use a barrier method as well, or switch to a non-oral contraceptive, for 30 days after starting Foundayo® and for 30 days after every dose increase. Speak to a clinician or pharmacist about the option that suits you best.

Foundayo® is not right for everyone. Tell us before treatment if you:

• are pregnant, trying to become pregnant or breastfeeding
• have had pancreatitis
• have severe delayed stomach emptying or significant digestive disease
• have gallbladder disease
• have kidney problems or are prone to dehydration
• take medicines for diabetes, particularly insulin or a sulfonylurea
• have diabetic eye disease or unexplained changes in vision
• take treatment for high blood pressure, or often experience low blood pressure or dizziness
• have severe heart failure
• are due to have surgery, anaesthesia or deep sedation
• take any of the medicines or herbal products listed in the interactions section

Pregnancy and Breastfeeding

Do not take Foundayo® during pregnancy or while breastfeeding. Stop Foundayo® at least three weeks before a planned pregnancy and speak to your clinician about alternative care. If you become pregnant while taking it, stop and contact a healthcare professional.

Complete your consultation accurately, including any weight management medicine you have used before. The more our clinicians know, the safer the decision they can make for you.

If you are currently using another weight management medicine and are considering switching to Foundayo®, our clinicians can assess whether changing treatment is appropriate for you.

Foundayo® contains orforglipron. Wegovy® contains semaglutide and Mounjaro® contains tirzepatide. Although these medicines all help reduce appetite and increase feelings of fullness, they are different molecules and work differently within the body. For this reason, there is no direct dose equivalence when switching between them.

Many patients consider switching because they:

• Prefer taking a once-daily tablet rather than a weekly injection.
• Want to avoid needles or injection devices.
• Travel frequently and would prefer a treatment that does not require refrigeration.
• Would prefer a tablet with no food, drink or timing restrictions.
• Wish to explore an alternative treatment following side effects or personal preference.

Every patient is different, and our clinicians will review your current treatment, weight loss progress, medical history, treatment goals and any side effects before recommending whether Foundayo® is appropriate for you.

What Dose Will I Start On?

Because Foundayo® contains a different active ingredient to the other weight management treatments we supply, there is no fixed dose conversion between them.

When reviewing your assessment, our clinicians will consider:

• Your current treatment and dose.
• How long you have been receiving treatment.
• Your response to treatment and weight loss achieved.
• Any side effects you have experienced.
• Your medical history and any other medicines you take.

Depending on your individual circumstances, you may not need to restart treatment at the lowest Foundayo® dose. Your clinician will recommend the most appropriate starting strength and advise when to stop your current treatment and begin Foundayo®.

Do not take Foundayo® at the same time as another GLP-1 medicine unless a clinician has specifically told you to.

Things to Consider Before Switching

Clinical studies have shown that Mounjaro® has demonstrated average weight loss of up to 21% and Wegovy® Pill approximately 14–17%. Foundayo® has demonstrated average weight loss of approximately 12.4% in clinical studies.

However, the treatment associated with the greatest average weight loss is not always the most appropriate choice. Convenience, tolerability, side effects, lifestyle, personal preference and long-term treatment adherence are all important factors when selecting the right medication.

Foundayo® may be particularly suitable for patients who want a once-daily tablet with no food or drink timing restrictions, or who would prefer not to continue with weekly injections.

Our Clinicians’ View

For many patients, remaining on their current treatment may continue to be the most appropriate option, particularly if they are achieving good weight loss and tolerating treatment well.

However, if you would prefer a daily tablet, want to avoid injections, or feel Foundayo® would better suit your lifestyle, switching may be appropriate following a clinical assessment.

Our clinicians will carefully review your treatment history and discuss the potential benefits and considerations before recommending the option that best meets your individual needs.

Ready to Switch?

If you are currently using another weight management treatment and would like to explore whether Foundayo® is right for you, simply click "Start Assessment."

We will review your current treatment, determine whether switching is clinically appropriate, and if suitable, recommend the most appropriate Foundayo® starting dose and switching plan based on your individual circumstances.